Cefepime maxipime side effects, dosage, interactions drugs. Maxipime admixture compatibility information is summarized in table 15. Published data may report both compatibility and stability, however most evaluate compatibility alone. Cefepime has a broad spectrum of in vitro activity that encompasses a wide range of grampositive and gramnegative bacteria. Compatibility of cefepime and vancomycin during simulated. Qinteractive offers an array of subtests for assessing ability, achievement, executive function, speech and language.
Outpatient treatment with cefepime administered postdialysis threetimesweekly was effective and welltolerated in our patients. Pediatric guidelines for iv medication administration. Cefepime for injection is an antibiotic that is given either intravenously intramuscularly. Mildtomoderate uncomplicated or complicated urinary tract infections 0. Iv compatibility results are organized onto separate tabs, so that you can quickly access the route or method in which you are interested. Drug incompatibilities in the adult intensive care unit of. Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Trissel, fashp, 2010, american society of healthsystem pharmacists. Hvflcnvbzffhbtzkdacbomsan cefepime chemical compound. The nebraska medical center supporting evidence for alternate cefepime dosing substitution background cefepime cep is approved by the food and drug adminstration fda for the treatment of febrile neutropenia, empiric therapy of uncomplicated skin and soft tissue infection ssti, complicated intra. Cefepime is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine.
When this drug is given through a catheter or needle in your vein, the dose is usually given over the course of about 30 minutes two or three times per day. It is usually given every 8 or 12 hours for 7 to 10 days. Cefepime fda prescribing information, side effects and uses. Complicated urinarytract infections may affect the lower urinary tract or upper urinary tract pyelonephritis. Cefepime jordan university of science and technology. The resultant solution will be 100 mgml for the 500 mg and 1 g vials and 160 mgml for the 2 g vial. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Urosepsis is associated with mortality of up to 40% among critically ill patients. Or should the tube be discarded after the first medicine is.
Cefepime is given by a slow injection into a vein iv or by intramuscular im injection, usually once every 8 or 12 hours, or perhaps less often if you have kidney disease. Cefepime cefepime hydrochloride intravenous inj sol. It is important that you receive cefepime on a regular schedule because the drug works best when there is a constant amount in the blood. Even when the pathogen is known, the antibiotic regimen should provide broadspectrum empiric coverage for the possibility patients who received cefepime and patients who received other antibiotics. Find patient medical information for cefepime in dextrose 5 % intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The medicine is usually given at your doctors office or. Maxipime cefepime hydrochloride dose, indications, adverse. The decision to mix drugs should not be made without knowledge of their compatibility. Running multiple iv antibiotics at one time general. Compatibility of cefepime and vancomycin during simulated ysite administration of prolonged infusion article in american journal of healthsystem pharmacy 725. Pediatric guidelines for iv medication administration note. Cefepime for injection, chemical structure, molecular formula. Intravenous medicine administration is the administration of sterile preparations of medicines directly into a vein, via a peripheral or central line, for therapeutic reasons 2007.
Compatibility of cefepime and vancomycin during simulated y. Maxipime is a sterile, dry mixture of cefepime hydrochloride and larginine. It does say that cefipime and vanco are ysite incompatible but does not specify if they are safe from different iv sights, for this reason i wouldnt do it. A healthcare professional should be consulted before taking any drug. Currently there are multiple resources to use when answering the question of compatibility with parenteral nutrition. You can publish your book online for free in a few minutes.
Dec 02, 2011 this randomized pilot clinical trial studies how well giving prolonged infusion compared to standard infusion of cefepime hydrochloride works in treating patients with febrile neutropenia. Us20110152311a1 novel crystalline forms of trans7oxo6. Alternatively, constitute the 500 mg, 1 g, or 2 g vial, and add an appropriate quantity of the resulting solution to an iv container with one of the compatible iv fluids. Cefepime for injection is compatible at concentrations between 1 mgml and 40 mgml with the following intravenous infusion fluids. This emedtv page explores this topic, including a list of some offlabel unapproved uses for cefepime and an explanation on how the drug works. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Check tubing below ysite carefully for discoloration, cloudiness or precipitation blank do not mix. Cefepime must be given slowly, and the iv infusion can take about 30 minutes to complete. Prolonged or standard infusion of cefepime hydrochloride. Cefepime hydrochloride fda orange book approved drug. Cefepime maxipime side effects, dosage, interactions. Cefepime injection is used to treat bacterial infections in many different parts of the body.
Hi, i am an rn checking on some medications for a double lumen picc line. Evaluation of seven iv drug compatibility references by using. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, iv tubing, and other items used. This randomized pilot clinical trial studies how well giving prolonged infusion compared to standard infusion of cefepime hydrochloride works in treating patients with febrile neutropenia. Cefepime is a broadspectrum fourthgeneration cephalosporin with in vitro activity similar to that of cefotaxime or ceftriaxone against the common meningeal pathogens h. If you use other drugs or over the counter products at the same time, the effects of cefepime may change. In some embodiments, the form iv is characterized by an xray powder. If iv access or medication timing is a problem, the pharmacist may convert the order to the equivalent intermittent dosingregimen without a physicians order but must document the intervention.
To reduce the development of drugresistant bacteria and maintain the effectiveness of maxipime and other antibacterial drugs, maxipime should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Ysite compatibility of medications with parenteral nutrition. You may receive cefepime injection in a hospital or you. Intravenous compatibility chart free html5 flip book.
Cochrane handbook clarke 1999 which are based on the evidence of a strong. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. The physical and chemical compatibility of cefepime and vancomycin at concentrations typically used in prolongedinfusion cefepime infusions was assessed. This may increase your risk for sideeffects or cause your drug not to work properly. Iv solutions containing 140 mgml prepared using compatible iv solution, are stable for 24 hours at 2025c or 7 days at 28c. Administer by slow iv push over 5 minutes in adult patients iv push only in patients 12 years of age and older do not administer simultaneously with calciumcontaining solutions e. Cefepime has a low affinity for chromosomallyencoded betalactamases. Solutions of maxipime, like those of most betalactam antibiotics, should not be added to solutions of ampicillin at a concentration greater than 40 mg per ml, and should not be added to metronidazole, vancomycin, gentamicin, tobramycin, netilmicin sulfate, or aminophylline.
Oct 02, 2018 maxipime for injection is supplied for intramuscular or intravenous administration in strengths equivalent to 500 mg, 1 g, and 2 g of cefepime. The larginine, at an approximate concentration of 707 mgg of cefepime, is added to control the ph of the constituted. Since june 2012, twelve infections were treated with postdialysis cefepime in 9. Pn solutions are diverse in their composition and compatibilities with drugs can never be guaranteed. The stability of cefepime in the formulation axepim diluted with 0.
Cefepime injection can also be given intramuscularly into a muscle. Transfer the constituted solution to a volumetric flask,and dilute with solution a to obtain a solution having a concentration of about 2mg of cefepime per ml. Nov 01, 2018 cefepime hydrochloride and dextrose dosage and administration adult and pediatric population. Lactated ringers or hartmann solution, products, or continuous calciumcontaining infusions e. Results for by, cefepime, cefepime by injection, cefepime novaplus, injection. Cefepime intravenous interactions with other medication. Cefepime hydrochloride monograph for professionals. Drug incompatibility, administration, intravenous, critical care, pharmaceutical services, intensive care units. To mix or not to mix compatibilities of parenteral drug. Provide a wide range of cephalosporins which includes cefepime for injection sterile. The physical and chemical compatibility of cefepime and vancomycin at concentrations typically used in prolongedinfusion cefepime infusions was assessed berti et al 2015.
Giving cefepime hydrochloride over a longer period of time may be more effective than giving cefepime hydrochloride over the standard time. Samples from a typical ysite configuration of standardinfusion vancomycin and prolongedinfusion cefepime were collected at various time points during the simulated 4hour. Veterans often hit hard by deaths of fellow soldiers november 11, 2019. Bacterial endotoxins 85 where the label states that cefepime hydrochloride is sterile or that it must be subjected to further processing during the preparation of injectable dosage forms, it contains not more than 0. Cefepime is licensed for adults and children as young as two months old with certain bacterial infections. See what others have said about cefepime, including the effectiveness, ease of use and side effects. In hemodialysis patients, postdialysis treatment with intravenous antibiotics permits even severe infections to be managed on an outpatient basis. Cefepime for injection, usp is a sterile, dry mixture of cefepime hydrochloride and larginine. Maxipime cefepime dosing, indications, interactions, adverse. Cefepime injection route description and brand names mayo. Iv geriatric patients, debilitated patients, or asa iii iv patients. To use the trissels iv compatibility module, select the trissels iv compatibility option when prompted. Cefepime works by decreasing the amount of bacteria in the lungs.
Intravenous drug incompatibilities were identified based on an analysis of the patient. Maxipime cefepime dosing, indications, interactions. We strove to evaluate and present the available published data as a comprehensive and practical reference. Prolonged or standard infusion of cefepime hydrochloride in. Ysite injection drug compatibility chart for general wards. If you have more than one iv compatibility database downloaded on your app, you may be prompted to make a selection. Drug incompatibilities in the adult intensive care unit of a university. We report on the pharmacokinetics of cefepime in postdialysis therapy. This medication belongs to a class of drugs known as cephalosporin antibiotics.
Pronunciation of cefepime with 1 audio pronunciation, 4 translations and more for cefepime. Cefepime hydrochloride is a white to pale yellow powder. Cefepime compatibility reconstitution and stability wikidoc. Trissels 2 clinical pharmaceutics database clinical. Cefepime is a bactericidal drug that acts by inhibition of bacterial cell wall synthesis.
Cefepime is a drug from the group of medicines called cephalosporins. Dailymed cefepime cefepime hydrochloride injection. Within bacterial cells, the molecular targets of cefepime are the penicillin binding proteins pbp. Parenteral nutrition pn and drug compatibility the coinfusion of drugs and pn should be avoided. If intravenous drugs are not mixed but are given consecutively, the infusion line should be flushed through with compatible fluid between each administration. I would like to know if vancomycin and ceftriaxone are compatible with tubing. For intravenous infusion, constitute the 1 g or 2 g piggyback 100 ml bottle with 50 or 100 ml of a compatible iv fluid listed in the compatibility and stability subsection. Easily administer and score clinical assessments using 1. Cefepime dosage forms include injection and infusion, and should be administered only by health care team.
Cefepime injection comes as a powder to be mixed with liquid, or as a premixed product, to be injected intravenously into a vein over a period of 30 minutes. Maxipime cefepime hydrochloride, usp for injection for. Incompatibility problems are more likely to arise when small. Ep2410981b1 dry powder formulations and methods for treating. For serious infections, it is usually best to give cefepime by iv rather than by intramuscular injection. Compatibility is denoted by an icon and simple description. Ceftolozanetazobactam zerbaxa, merck september 2015. Severeuncomplicatedorcomplicatedurinarytractinfections,moderatetosevereuncomplicatedskinandskinstructureinfections,complicatedintraab.
Cefepime usual diluents d5w, ns standard dilution amount of drug infusion volume infusion rate 0 to 2 grams 50 ml 30 min reconstitution for intravenous infusion, constitute the 1 g or 2 g piggyback 100 ml bottle with 50 or 100 ml of a compatible iv fluid. Guidelines recommend cefepime plus vancomycin, gentamicin, and rifampin if prosthetic material is present for culturenegative nosocomial endocarditis associated with vascular cannulae or early less than 1 year after surgery prosthetic valve endocarditis. To access the iv compatibility module, open the lexicomp app and select the iv compatibility icon from the home page. According to our data, in patients infected by highly susceptible pathogens a fixed dose of cefepime of 1 g before every 48h interval and of 1. Incompatibilities are based on meeting any of the following criteria. Ive consulted the drug book and found that no contraindications exist for giving vanco and flagyl at once.
Test solution constitute one container of cefepime for injection with a volume of solution a equivalent to the volume of solvent specified in the labeling,and shake to dissolve. Cefepime hydrochloride monohydrate has a molecular mass of 571. Cefepime maxipime 2g in d5w 100 ml ivpb 2 g 200 mlhr ivpb. As of 20, this field contains the consumer friendly descriptions for the ama cpt codes. We selected 55 injectable drugs analyzed individually with two types of parenteral nutrition. Cefepime hydrochloride and dextrose fda prescribing. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Oct 02, 2018 cefepime is injected into a vein through an iv.
Cefepime for injection usp and dextrose injection usp in the duplex container should be used only in patients who require the entire 1 or 2 gram dose and not any fraction thereof. Cefepime is injected into a large muscle, or added to an intravenous iv fluid that drips through a catheter in your vein for 30 minutes. A legend at the bottom of the page lists all compatibility types, and hovering your mouse over the icon will open a popup with the full. Study includes monotherapy and combination treatment groups compatible with the protocol, but. Threetimesweekly, postdialysis cefepime therapy in. Calcium chloride ampicillin ampicillin yes calcium. Critical care intravenous drug administration guide. Treatment of uncomplicated skin and skin structure infections. Cefepime hydrochloride contains the equivalent of not less than 825 mcg and not more than 911 mcg of cefepime c 19 h 24 n 6 o 5 s 2 per mg, calculated. Reconstitute vials containing 500 mg, 1 g, or 2 g of cefepime with 5, 10, or 10 ml, respectively, of compatible iv solution to provide solutions containing approximately 100, 100, or 160 mgml, respectively. Heart disease took big toll in counties hardest hit by recession november 20, 2019. Food and drug administration fda is reminding health care professionals about the need to adjust the dosage of the antibacterial drug cefepime in patients with renal kidney impairment. Drusano 1985, study includes monotherapy and combination treatment groups compatible. Drugs administered to patients receiving pn should be given through a separate iv site or catheter lumen.
Cefepime has been examined for stability, potential liberation of degradation products and compatibility with other drugs under conditions mimicking its potential use by continuous infusion in cystic fibrosis and intensive care patients 512% wv solutions. Maxipime cefepime hydrochloride for injection side effects. Areas hit hardest by recession saw jump in heart death rates november 22, 2019. Cefepime belongs to antibiotics, used in the treatment of infections. Intravenous betalactam antibiotic given as monotherapy, including. The analysis included one print reference handbook on injectable drugs, 14th edition and six electronic i. The larginine, at an approximate concentration of 707 mgg of cefepime, is added to control the ph of the constituted solution at 4 to 6. List of approved drug products containing cefepime hydrochloride in the fda orange book on approved drug products containing cefepime hydrochloride listed in the fda orange book. Order, request a free trial, or contact the sales team. The usual dose for adults with cf is 2 grams twice a day by iv infusion. Add 5 ml of compatible iv diluent to each 500 mg vial or 10 ml of diluent to each 1 g or 2 g vial. Cefepime is used to treat a wide variety of bacterial infections.
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